We are in constant pursuit of breakthroughs that change patients' lives. We innovate each day to make the world a better place. This was Charles Pfizer's original vision, and it remains true today. Evidence confirms what intuition tells us: that purpose-driven companies perform better, are more creative, draw and keep the best talent, and know how to maximize the power of those individuals. Pfizer's purpose—Breakthroughs that transform patients' lives—fuels everything we do and reflects our passion for expanding our legacy as one of the most important contributors of good to the world. Each word in our purpose has meaning and embodies the value we work to bring to patients and society. Our purpose makes certain that patients remain at the centre of all we do. We embody our purpose by seeking the best science in the world, collaborating with others in the healthcare system to enhance access to our medicines, employing digital technologies to enhance our drug discovery and development, as well as patient outcomes, and leading the conversation to advocate for pro-innovation/pro-patient policies. Every decision we make, and every step we take is done with the patient in mind—and to foster an environment where breakthroughs can prosper.